다양한 NSAID가 인간 치주인대세포의 prostaglandin 합성 및 세포 형태에 미치는 효과에 대한 연구
Effects of various NSAIDs on prostaglandin synthesis and cellular configuration of human periodontal ligament cells
김혁수, 심혜영, 채창훈, 장영일, 박준우,
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김혁수 ( Kim Hyeok-Soo ) - 서울대학교 치과대학 교정학교실
심혜영 ( Shim Hae-Young ) - 서울특별시립 보라매병원 치과
채창훈 ( Chae Chang-Hoon ) - 나노큐어텍 나노-바이오 퓨전 부설연구소
장영일 ( Chang Yong-Il ) - 서울대학교 치과대학 치과교정학교실
박준우 ( Park Jun-Hu ) - 한림대학교 의과대학 치과학교실
KMID : 0355620070330050455
Abstract
The present study was designed to evaluate effects of the commonly used NSAIDs(acetaminophen, aspirin, and ibuprofen) on human periodontal ligament cells. Human periodontal ligament cells were grown from a cell line provided by Kyungpook National University. Effects of NSAIDs on the proliferation of human periodontal ligament cells were assessed using MTT assays. And then PGE2 concentrations were determined by ELISA and the changes of cellular configuration were found by electron micrograph. The results were as follows; 1. The MTT assay demonstrated that the commonly used NSAIDs(acetaminophen, aspirin, and ibuprofen) had not significant cytotoxic effect on human periodontal ligament cells. 2. NSAIDs inhibited the PGE2 synthesis of human periodontal ligament cells compared with the control group. These inhibitory effects had no significant differences with NSAID type and concentration. 3. Electron micrographs of human periodontal ligament cells treated with NSAIDs showed more narrow and irregular shape.
키워드
NSAID;Human periodontal ligament cell;Prostaglandin;Electron micrograph
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